Letter: Serum creatin phosphokinase and malignant hyperpyrexia.
نویسندگان
چکیده
منابع مشابه
Evaluation of creatinine phosphokinase in screening patients for malignant hyperpyrexia.
Evidence is presented that serum creatinine phosphokinase (CPK) activity is of no direct value in screening patients for susceptibility to malignant hyperpyrexia and does not correlate with halothane-induced muscle contracture or the presence of myopathy. Widely differing CPK values were found at different times in the same people. In most "malignant hyperpyrexia" families the susceptible patie...
متن کاملRhabdomyolysis and malignant hyperpyrexia.
detected in any patient by this method. Fourteen patients had raised serum creatine kinase activity (up to 5000 IU/1, normal range < 170 lU/i) and raised serum aspartate transaminase activity (up to 150 IU/1, normal < 35 IU/1). In all cases enzyme activity fell after admission to hospital. Peak serum creatine kinase activity was not significantly related to weight, sex, level of consciousness, ...
متن کاملMalignant hyperpyrexia. Further muscle studies in asymptomatic carriers identified by creatinine phosphokinase screening.
The history, clinical presentation, and management of malignant hyperpyrexia are presented. The aetiology seems to be associated with some inherited abnormality which affects the movement and binding of calcium ions in the sarcoplasmic reticulum, sarcoplasm, and mitochondria. Whether this is a primary muscular defect or secondary to some trophic neural influence is yet to be established. The su...
متن کاملProcaine in malignant hyperpyrexia.
The caffeine contracture of normal human muscle, which has been used as a model for malignant hyperpyrexia, is greatly potentiated by halothane. Prior administration of procaine markedly reduces the halothane-potentiated caffeine contracture, and procaine given at the height of the contracture induces relaxation. Lignocaine, on the other hand, produces a variable response and sometimes increase...
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We are, indeed, fortunate in the Anesthesia Department at North Carolina Baptist Hospital to have an excellent supply of equipment. Yet, we are guilty, at times, of failing to take full advantage of it. A prime example is the temperature probe, a valuable aid in the diagnosis of malignant hyperpyrexia. In fact, it is so important that failure to monitor body temperature during anesthesia may ha...
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ژورنال
عنوان ژورنال: BMJ
سال: 1975
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.4.5993.408-a